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Earth system box models are essential tools for reconstructing long-term climatic and environmental evolution and uncovering Earth system mechanisms. To overcome the spatiotemporal resolution limitations of current deep-time models, a research team has developed CESM-SCION, a new-generation high-resolution climate-biogeochemistry coupled model. This model advances the spatiotemporal resolution of long-term Earth system simulations to a new level and identifies marine regression as a key driver of the Late Paleozoic Ice Age onset.